QSPC2020

QSPC2020

QSPC2020

Satellite events

Advanced QSP Modeling – From Clinical Data to Virtual Subjects, Cohorts, and Populations

April 21st 2020

 
On Tuesday, April 21, 2020, IntiQuan welcomes you to a full day hands-on workshop on advanced QSP modeling!
 
Special emphasis is put on the estimation of individual parameters based on clinical data, allowing to determine Virtual Subjects, Cohorts, and Populations in an estimation-based approach that is suitable even for large scale models and a large number of patients in the considered data. The ability to estimate such individual level parameters in QSP models has the potential to open up advances in diagnostics through the use of advanced statistical methods. The workshop is designed as a hands-on tutorial. Each topic will first be presented on slides
and will be illustrated based on realistic examples. Between topics, the participants will have the chance to implement and reproduce the different steps on their own using the provided example model.
 
For more details and registration, go to: https://www.intiquan.com/qspc2020/

Quantitative systems pharmacology model development using gQSPSim: a GUI-based open-source platform for SimBiology models

April 22nd 2020

 

gQSPSim is a comprehensive GUI-based MATLAB app developed by Genentech to perform key processes in QSP model development and analyses (Fig. 1):

  1. Model calibration to data using global and local optimization methods (scatter search, particle swarm)
  2. Developing virtual patient populations to explore variability and uncertainty in the underlying system biology
  3. Predictions for virtual populations for interventions of interest (therapies, genetic alterations, etc)

gQSPSim works with any SimBiology model and provides an interactive interface for all features, and the ability to generate presentation-ready figures, and save and share working sessions for future use. 

In this half-day workshop, we will introduce the gQSPSim framework, building blocks and functionalities. The application and features of gQSPSim are demonstrated using 1) a standard target-mediated drug disposition (TMDD) model, and 2) a published PCSK9 QSP model (Gadkar et al. 2014). Workshop attendees will be instructed on how to use the app to perform the QSP model development key processes listed above. We will explore the use of acceptance criteria to generate virtual cohorts under different scenarios and use visual diagnostic tools to compare virtual patients with the pre-specified range of measurements.  Lastly, we will use statistical data to generate a virtual population from a virtual cohort.

Instructors:
Dr. Kapil Gadkar, Genentech
Dr. Iraj Hosseini, Genentech
Jeremy Huard, MathWorks

 

For more details and registration, go to: https://www.mathworks.com/company/events/seminars/quantitative-systems-pharmacology-model-development-2954639.html

Please note that satellite events are not organized by the QSPC2020 organization, for details or questions please contact the organizers of the event directly.

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